D-optimal Design for Preparation and Optimization of Fast Dissolving Bosentan Nanosuspension
نویسندگان
چکیده
منابع مشابه
D-optimal Design for Preparation and Optimization of Fast Dissolving Bosentan Nanosuspension.
PURPOSE Bosentan is a drug currently taken orally for the treatment of pulmonary arterial hypertension. However, the water solubility of bosentan is very low, resulting in low bioavailability. The aim of this study was preparation and optimization of bosentan nanosuspension to improve solubility and dissolution rate. METHODS The different formulations designed by Design Expert® software. Nano...
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ژورنال
عنوان ژورنال: Advanced Pharmaceutical Bulletin
سال: 2016
ISSN: 2228-5881,2251-7308
DOI: 10.15171/apb.2016.029